Pharmacotherapeutic effect of methanolic and ethanolic extract of Spinacia oleracea L. leaves on glycemic and lipidemic indexes of alloxan-induced diabetic mice

With the various side effects associated with synthetic medicines for treating diabetes, there is a need to develop herbal remedies as an alternative. Although Spinacia oleracea L. leaves are used treat health conditions, including little research validate its antidiabetic properties. This study aimed investigate hypoglycemic and hypolipidemic effect of methanolic ethanolic extracts against alloxan-induced hyperglycemia in mice. Hyperglycemia was induced by injection alloxan monohydrate 80mg/kg bw. (i.p.). After 72 hours, mice Blood Glucose Levels above 11.0 mmol/L were selected investigation. Both at 200 mg/kg doses observed have 21 consecutive days. Level monitored after 3, 6, 9, 12, 15, 18, days compared Glibenclamide (0.5 b.wt.). Serum lipid profile [total cholesterol, triglycerides, low-density lipoprotein, high-density lipoprotein] liver enzymes such SGPT, SGOT also determined. Oral administration both showed significant (P < 0.05) antihyperglycemic activity diabetic The had 0.01) reduction blood glucose; serum enzyme level (SGPT SGOT) normal